Bovine adrenal medulla (BAM) peptides are peptides secreted in the adrenal gland that exhibit potent opioid activity1.

BAM peptides were first purified from bovine adrenal medulla and it was found that upon their trypsinization they can yield the other enkephalin peptide-Met Enkephalin2.

BAM peptides are cleavage products of the opioid peptide, pro-enkephalin. There are atleast three different BAM peptides that have been identified so far: BAM 12P, 20P and 22P3.

BAM 22P is a docosa peptide that is a cleavage product of pro-enkephalin. BAM 20P and BAM 12P are C-terminal shortened versions of BAM 22P2.