For women, morbid obesity (defined as a BMI of 35 or greater) was shown to be associated with a more than 12-fold risk of diabetes, an almost 12-fold risk of knee replacement, a sixfold risk of heart failure, a fivefold risk of high blood pressure and gallbladder removal, and a fourfold risk of potentially life-threatening clots to the lungs, chronic fatigue/lack of energy, and insomnia.

Acomplia diet pills not only cause weight loss, but prevent or reverse the metabolic effects of obesity, such as insulin resistance and hyperlipidemia, and may also decrease the tendency to abuse substances such as alcohol and tobacco.