
The 69-year-old boxer will appear at three dinners held in his honour at British sports stadiums next month.
The former heavyweight, who has suffered from Parkinson's Disease since 1984, is well enough to travel but the situation could change in future years, a spokesman said.
Ali will be raising money to support his various charities including his cultural centre in his home town of Louisville, Kentucky.
Having last visited several years ago, he said: "The UK is very close to my heart. I want to visit again not only to raise awareness and funds for the Muhammad Ali Centre, but also to revisit such a wonderful country and to all my friends and fans here."
"We're looking forward to reconnecting with old friends and to garner support for Muhammad's charities."
Tickets to the events are available through www.mammothevents.co.uk or 0845 612 2008.