In a study on moderately obese male and female subjects, polyphenols extracted from apples were shown to significantly lower cholesterol. Apples are also high in pectin, a soluble fiber with the ability to lower cholesterol, and it has been demonstrated that an apple a day can lower cholesterol by up to 16 percent.

Studies have shown that quercetin found in apples reduces the cancer risk of prostate cancer, ovarian cancer, breast cancer, and colon cancer.

Regular consumption of apples can promote healthy weight loss.
Results from a clinical trial conducted involving forty-nine women indicated that energy densities of fruits could help to promote weight loss over time.In a study of overweight women, weight loss was associated with a diet supplemented with 3 apples a day.

In an in vitro study at the Boston University School of Medicine, it was concluded that the flavonoid quercetin, which is present in apples, has anti-inflammatory activity.