Researchers are testing a new way to kill cancer cells selectively by attaching cancer-seeking antibodies to tiny carbon tubes that heat up when exposed to near-infrared light.
Scientists are able to use biological molecules called monoclonal antibodies that bind to cancer cells. Monoclonal antibodies can work alone or can be attached to powerful anti-cancer drugs, radionuclides or toxins to deliver a deadly payload to cancer cells.
In this study, the researchers used monoclonal antibodies that targeted specific sites on lymphoma cells to coat tiny structures called carbon nanotubes.
In cultures of cancerous lymphoma cells, the antibody-coated nanotubes attached to the cells' surfaces. When the targeted cells were then exposed to near-infrared light, the nanotubes heated up, generating enough heat to essentially "cook" the cells and kill them.
This was true even when the antibody-nanotube complex was placed in a setting designed to mimic conditions inside the human body.